Yeah, I sometimes go for a generic defensive build, using shotguns since they work fairly well even if you don't go for the Shottyman/Hellrunner approach. (I often pick up Juggler, one double shotgun in each hand and no switch time = fun). If I do that I usually end up with four or five weapons, so the extra slots would be nice, but it could easily be too much. The inventory is supposed to be tight.
That said, I don't pick up EE if I do that since I don't really need it, so I still wouldn't use it. Would be rather nice for a rapidfire build, perhaps.
The other reason I find I need space is that I usually find weapon mods before I find an advanced weapon, so if I want to take the Wizkid approach, I end up lugging a bunch around for later. So glad that advanced RL is always guaranteed to show up around lvl 10.....