Man, now I kinda wish that I found the DS much later. Still 300 floors to go, and it's a long way ahead to kill everything until the last floor. A few things I found:
-Things can get hairy if my player wasn't berserk all the time. Without hellrunner, a lot of enemies get a ton of hits on me, especially if I'm not wearing the antigrav boots. If I'm surrounded by a crowd, it gets extra tedious since nearly everyone would be pushed farther away by all the splash damage. Thankfully, having two points in badass doesn't push me away when I have to move forward.
-On the other hand, that was mostly a problem before getting hold of the dragonslayer. Berserk, plus three points in tough as nails, and a cerberus armor makes damage next to none. Almost any single shot hits me for one percent... out of two hundred percent. Maxed made of iron and badass and having vampyre ensures that I stay safe all the time. Aside from nightmare arachnotron caves, I end every floor at max health even without using any health powerups. Vampyre recovers more health than the damage I get most of the time.
-Adding to that, I went with a cerberus armor mod using an onyx armor. Since I no longer need an onyx pack to fix the durability issue, I used a power mod pack to further add more defense to me. On one hand, I get damaged by lava and acid floors again. On the other hand, that's also a no issue since it only takes a single point of damage per step. I've noticed that sometimes I won't get damaged at all.
-Before dragonslayer pick up, shambler-only floors are surprisingly dangerous. They have a tendency for all of them to teleport on one room, and being backed into a corner almost done my player in.