I've just installed the Beta client on my Windows 10 laptop. It's this one:
https://www.msi.com/Laptop/ge62-2qf-apache-pro.html, main specs are a GTX970M Graphics Card and an i7-4720HQ proc. No external device is connected (neither moues nor keyboard)
Game launches fine, but when I try to play, the input (arrow keys or keyboard keys) does not register. Alt tab doesn't work. Alt Ctrl Del works, and the kicker is that the last action actually goes through while I'm on the alt ctrl del menu: I hear the corresponding sounds and when I come back the action is registered. So I can play frame by frame by Alt Ctrl Deling between every move. That's not very practical though.
If there's a log somewhere I should post, I'd be happy too