Just as the topic says: what traits do you use, and why? Have you tried anything insane for kicks, and did it work?
For myself, I use Tough as Nails 3, Eagle Eye 1 and Cateye 2 (usually picking up Cateye after 2 TaNs). TaN is great for early survivability (when everyone does low damage), despite its lesser usefulness in later levels. Cateye is indispensible for picking off everything without taking a scratch (until the next release, anyway). Eagle Eye (plus berserk) means that I hit with the chaingun about 90% of the time, and maybe a little closer to 60-80% with the plasma gun. I've usually found that rocket launchers and plasma guns do enough on their own to make SoaB somewhat less useful, but I spend most of my endgame exploiting Cateye to its max rather than wading wild-eyed into combat.
Every now and then, I try a Pistoleer run with maxed Finesse and Son of a Gun, but I usually die hideously despite firing the pistol like a chaingun. Has anyone had better luck?