do you have any trouble dealing with tough guy like JC or cyber? can you give some advice for doing a run like this?
From last to start:
JC: easy. I have a MVm and Bru*5 and Berserk, and JC summon sculls first. And shoot rocket at them, kill all and hurt himself. Then repeats. I do not touch him until he summon knights. I think he hurt himself for 50% and I hit him for another 50.
Mastermind: it can be a problem... but I nuke level :)
Lava Pits: easy. I have an antigrav boots and envirosuits. Speed is a key - if mankubi rocket explodes to close for them, they knocked himself to lava and die at next turn. I think that on HNTR and ITYTD difficulties Lava Pits more difficult for melee char, actually.
Arch-viles level was the easiest level from all previous. Only archviles. Dispersed on a big level so only one arch-vile at a moment.
Mortuary: speed is a key - I use hatred skull then run to left, killing viles before they spawn a lot enemies. then run to right - it can be hard, but berserk has a 60% to all resistance :)
Vaults: open with missile launcher first and last vault, then use a staff for opening middle one. Of course using staff immediately not wise for melee char...
Cyberdemon: He can be a BIG problem but I got Invulnerability just before descending here.
Spiders: I think I dead man... twice. Use all medpacks.
City of sculls: easy with Bru*3 and MVm.
Anomaly: rocket jump away, kill in door one by one all enemies. For BBs use a missile launcher till they are "severely wounded" then run and kill them in melee. Past Anomaly melee char can kill anything. Do not forget about weapons - it was not a Angel of Berserk, so I can (and use) shotguns and rocket/missile launchers for hurt touch enemies to "severely wounded" or even "almost dead" state.
The hardest part was first 7 levels. And Hell Arena, Chained Court and The Wall. I have about 8 small medpacks and 1 large on level 2 - so I try Arena. Usually I evade it, or die here :)