everything dies in one hit? what's the point? Int2+shotguns = pwnage. The main trouble will be to get to the shotgun unscathed. Also, it will nullify most objects from being useful. Armor? It does not help you not die from that very first hit. Get Tac/A or phaseshift/A and run as hell, only running saves there. Boots? The same. Weapons that don't autohit? Well, blowing up walls require some of them indeed, but a shotgun/T is your ultimate friend when facing monsters. Medpaks? Har har har, their only use will be giftdropping, but why the hell giftdropping, if you can shoot into the darkness and lay waste to everything hiding in there? Envirosuit? Yes - maybe even more, as you cannot afford dipping your feet into lava/acid anymore. Mod packs? Well, they will have less use, since why assembling fireshields/stuff when anyway you take that one damage that kills you if you are hit. The most you will need 6 A packs and up to 1 N pack, plus 2 T packs and 1 P pack (with optional 3 T packs for micro launcher/T). Everything else is plain useless/counterproductive.
Angel of Fragility alone? Well, here things start to get ugly. Someone can already do a "standard N! damageless run", so he's already a master at this challenge, while most of DoomRL players will ragequit indeed.