I'm playing Skyrim with permadeath. If I die, I delete all my savefiles.
O_O
Uh, I don't know... permadeath on such long games doesn't really feel too great. Even in ToME I sometimes really dislike it (though I'm actually pro permadeath in general). You explore the world for hours and hours, get somewhere you've never been before, something strange happens and BAM... that's it. And you explore the (structurally same) world again.
Therefore I'm playing smaller roguelikes mostly at the moment: DoomRL of course, as well as all the other ChaosForge titles once again. Some Brogue occasionally. At the same time eagerly awaiting the upcoming Project Zomboid update. ;)