Short answer: No.
Longer answer: None of the uniques are particularly balanced; a few of them are super useful beyond belief, (like Malek's Armor or Dragonslayer) but a majority of them I just throw away immediately. (There are no circumstances I would use Mjollnir or the Frag Shotgun, for instance) It kind of feels like, in the latest version of DRL, the devteam just threw a random bunch of special items into the game without giving it a lot of thought.
I understand the theory behind how Charch's Null Pointer works, but every time I've tried putting it in practice, it's just a waste of cells. A regular plasma rifle would be a better use of the ammo.