Just an idea or two
Blind Eye - Areas outside of your field of vision will always look like walls(or something else).
Unnerved - All ranged weapons have a higher chance of missing.
Horrid Curse (Desperate need of renaming)- Monsters around you (2 squares around) have a chance of taking 1d2 damage every turn, however, healing items that are used instantly (such as Small health globes, berserk packs, invunurabilty globes, supercharge globes, ect.) have a chance of doing nothing, or less then normal, or damaging you by a small fraction of what it heals. With no Ironman, A supercharge may take you just from 100% to 120% or to 90% and berserk packs may just heal you and whatnot.
Sacrifice - At the end of every level, one or two of your items of a certain group (Such as usable, or amm or guns or armor) are put in a list, then some chosen at random are confinscated and destroyed.
Dazed State of mind - After ten steps, the next six make you move in a random direction, then they start to loop.
Weak body(Also needs chainging) - Melee damage(if you ever use it) is reduced, and every bullet that hits you (not imp or BOH shots, but from a pistol, shotgun, chaingun, and so on) will cause you to start bleeding